Awarded Project: "Salmonella-specific Th1 cell function and residence"

Salmonella-specific Th1 cell function and residence

Dr. Stephen J. McSorley was awarded a five year grant from the National Institute of Allergy and Infectious Diseases, NIH.  Systemic Salmonella infections are responsible for almost 1 million deaths annually and there is an urgent need to understand the mechanisms of protective immunity. Host CD4 T cells responses are critical for protective immunity to Salmonella in humans and in mouse models but there is a knowledge gap in relation to the functional requirements for memory CD4 T cells during a protective response. This application will examine two functional aspects of protective Salmonella-specific CD4 T cells in an attempt to understand why some immunization strategies succeed and others fail to protect against infection.