Helicobacter pylori commonly infects the stomach, where it can cause peptic ulcer disease or gastric cancer. Numerous H. pylori vaccines have been studied in the mouse model, but sterilizing immunity has typically not been achieved, and the results have rarely been extended to primates. The Solnick lab is exploring the use of immunization with H. pylori outer membrane proteins as a preclinical approach to primary and secondary prevention of H. pylori infection. A licensed AIDS vaccine does not exist and the currently licensed influenza vaccines are difficult to produce, provide less than optimal protection even from antigenically matched challenge viruses, and little protection against mismatched virus. The Miller lab utilizes non-human primate models of AIDS and influenza A virus infection to define the nature of protective antiviral immunity, and test vaccines and immunotherapeutic strategies to prevent AIDS and influenza. A vaccine to protect against the congenital transmission of cytomegalovirus (CMV) is a top public health priority. Efforts to develop such a vaccine in the CMV macaque model are well in progress at the Center for Immunology and Infectious Diseases and the California National Primate Research Center.